BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany; Freie Universität Berlin, Institut für Pharmazie, Pharmakologie und Toxikologie, Berlin, Germany. Electronic address: andreas-georg.weber@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address: barbara.birk@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address: chantal.mueller@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address: steffen.schneider@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address: bennard.ravenzwaay@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address: dorothee.funk-weyer@basf.com. BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany; Freie Universität Berlin, Institut für Pharmazie, Pharmakologie und Toxikologie, Berlin, Germany. Electronic address: robert.landsiedel@basf.com.